We are not only virologists! We also like to do structural biology. In particular, we are interested in thin-section TEM of biological samples. This interest has helped us to open our doors to many people from other laboratories. They can come to learn how to process samples, or we can collaborate to process them for them. At any rate, the goal is to use our TEM expertise to help anyone who wants to collaborate. We are interested in developing new protocols to process “tough” samples and pursuing novel approaches.

 

The collaborative projects that we have established (or that we are establishing) are:

• Finding emerging viruses in tissues of wildlife and laboratory animals (Prof. Christian García-Sepúlveda).

• Ultra-structural changes at the Brain-Blood-Barrier (Profs. Saderi and Salgado-Delgado)

• Ultra-structural changes in plant cells (Prof. Margarita Rodriguez-Kessler).

• Purifying and characterizing by TEM viral particles from San Luis Potosí's sewer systems (Prof. Daniel Noyola Cherpitel) (see image below).

• Characterizing novel phages that kill antibiotic-resistant bacteria (Prof. Fidel Martínez).

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Published articles on this topic:

1. Ulloa-Medina, O.U., Hernández-Sánchez, P.G., Mata-Moreno, G., Jaime-Rocha, L.R., Alatorre-Camacho, S.C., Lara-Hernández, I., Comas-García, M., Muñoz-Escalante, J.C., González-Ortiz, A.M., Torres-González, P., and Noyola, D.E. (2026) Wastewater-based surveillance of respiratory viruses in the SARS-CoV-2 post-pandemic period in Mexico. Viruses. 18(2), 254 

2. Jurado-Sánchez, N., Espinosa-Reyes, G., Comas-García, A., Díaz Barriga-Martínez, F., Comas-García, M., Guerra-Palomares, S.E., García-Sepúlveda, C.A. (2025). Assessment of a low-cost mosquito-borne disease early warning system integrating molecular mosquito and arbovirus surveillance. Zoonoses and Public Health. 0:1-14 

3. Ruiz-Hernández, S., Ochoa-González, F.L., Catañeda-Delgado, J.E., Galicia-Cruz, O., Castillo-Velázquez, R., Comas-Garcia, M., Rivera, G., Lara-Ramírez, E.E. (2025) Computer-aided repositioning and functional in vitro assessment of novel PAD4 inhibitors. RSC Medicinal Chemistry. 16, 4405-4414 

4. González-Sánchez, H.M., Rubio-Hernández, E.I., Silva-Ramírez, A.S., Miranda-López, A., Monsivais-Urenda, A.E., Comas-Garcia, M., Noyola, D.E., Rodríguez, V.M., Castillo, C.G., (2025). Cytomegalovirus Infection Affects the Differentiation and Determines the Functionality of a Human Progenitor Neural Cell Line. Current Microbiology 82:25 

5. Hernández-Aviña, A.D., Mendoza-Gómez, L.F., Hernández-Mancillas, X.D, Salazar-Gonzalez, J.A., Zapata-Cuellar, L., Camacho-Ruiz, R.M., Comas-García, M., Sarmiento-Silva, R.E., Rodríguez, J.A., Arellano-Plaza, M., Flores-Valdez, M.A., & Gutiérrez-Ortega, A. (2024).Design of a Golden Gate Cloning Plasmid for the Generation of a Chimeric Virus-Like Particle-Based Subunit Vaccine Against Porcine Circovirus Type 2. Mol Biotechnol. doi: 10.1007/s12033-024-01334-z 

6. Moreno Valtierra, M., Urue Corral, A., Jimenez Avalos, J. A., Barbosa  Avalos, Dávila-Rodríguez, E. S. J., Morales Hernandez, N., Comas-García, M., Toriz González, G., Oceguera Villanueva, A., Cruz-Ramos, J.A., Hernández Gutiérrez, R*., Martínez-Velázquez,  M.*, García Carvajal, Z.Y. * (2024) Patterned PVA Hydrogels with 3D Petri Dish® micro-molds Topography for HeLa Spheroid Formation: in vitro assessment. Gels. 10(8), 518

7. Sánchez-Medina, J.G., Cuellar Camacho, J.L., Mira, A., Martinez Martinez, R.E., Comas-Garcia, M., Garrocho Rangel, A., Pozos Guillen, A.J., Aranda Romo, S. (2024) Streptococcus dentisani inhibits the growth of Candida albicans and Candida glabrata. In vitro assays. International Microbiology. 

8. Velazquez-Cervantes, M.A., López-Ortega, O., Cruz-Holguín, V.J., Herrera Moro-Huitrón, L., Flores-Pliego, A., Lara-Hernández, I., Comas-Garcia, M., Villavicencio-Carrisoza, Helguera-Reppeto, A.C., Arévalo-Romero, H., Vázquez-Martínez, E.R., León-Juarez, M.* (2024) Metformin inhibits Zika virus infectin in Trophoblast Cell line. Current Microbiology. 81(5), 133 

9. Alvarez, M., Franco Vega, A., Ganem Rondero, A., Soria Guerra, R., Juarez Flores, B.I., Comas-Garcia, M., Oros Valle, C., Schneider, B., Ratering, S., Schnell, S., Martinez-Gutierrez, F., (2023) Modulation of the altered intestinal microbiota by use of antibiotics with a novel synbiotic on Wistar rats. Probiotics and Antimicrobial Proteins

10.  Lara-Hernandez, I., Escalante-Muñoz, J.C., Bernal-Silva, S., Noyola, D.E., Wong-Chew, R.M., Comas-Garcia, A*., Comas-Garcia, M.* (2023) Ultrastructural and functional characterization of mitochondrial dynamics induced by human respiratory syncytial virus infection in HEp-2  cell. Viruses. 15(7), 1518 

11. Rubio-Hernández, E.I., Comas-Garcia, M.*, Coronado-Ipiña, M.A., Colunga-Saucedo, M., Gonzalez-Sanchez, H.M.* Castillo-Martin del Campo, C.G.* (2023) Astrocytes derived from Neural Progenitor Cells are susceptible to Zika Virus Infection. PlosOne. 18(3): e0283429. 

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Updated: October 2026